InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
@@ -0,0 +1,115 @@
+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation
+{
+    public struct cellInfo
+    {
+        public double time;
+        public CellState state;
+        public Dictionary<string, double> resources;
+        public CellCaState caState;
+        public override string ToString()
+        {
+            StringBuilder sb = new();
+            sb.AppendLine($"Time: {time}, State: {state}");
+            foreach (var kvp in resources)
+            {
+                sb.AppendLine($"{kvp.Key}: {kvp.Value}");
+            }
+            return sb.ToString();
+        }
+    }
+
+    public class Cell
+    {
+        private List<Organell> organelles = new();
+        private CellRessources resources;
+        private CellState state = CellState.Resting;
+        private double time = 0.0;
+        private Random rng = new();
+        private CellCaState caState = new();
+
+        public EnviromentState EnviromentState { get { return resources.Env; } set { resources.Env = value; } }
+
+        public Cell()
+        {
+            organelles.Add(new Cytosol());
+            organelles.Add(new Mitochondrion());
+            organelles.Add(new Nucleus());
+            organelles.Add(new Membrane());
+            organelles.Add(new Lysosome());
+
+            resources = CellRessources.InitDefaults();
+            
+
+            // calcium baseline
+            caState.CytosolicCa = 0.0001; // 100 nM
+            caState.ER_Ca = 0.5;          // 0.5 mM
+        }
+
+        public void Step(double dt)
+        {
+            foreach (Organell organell in organelles)
+            {
+                organell.calculateRate(resources);
+            }
+
+            foreach (Organell organell in organelles)
+            {
+                organell.applyChanges(resources, dt);
+            }
+
+            CheckForDeath(dt);
+
+            time += dt;
+
+        }
+
+        private void CheckForDeath(double dt)
+        {
+            // Energie- und Calciumkritische Schwellen
+            const double ATP_MIN = 0.05;     // mM
+            const double CA_TOXIC = 0.002;   // 2 µM
+            const double WASTE_MAX = 5.0;    // mM
+
+            if (resources.Res.Energy.ATP < ATP_MIN || caState.CytosolicCa > CA_TOXIC || resources.Res.Protein.Waste > WASTE_MAX)
+            {
+                // langsamer Zelltod
+                if (rng.NextDouble() < 0.1 * dt)
+                    state = CellState.Apoptosis;
+            }
+
+            if (state == CellState.Apoptosis)
+            {
+                // Zelle verliert Ressourcen über Zeit
+                resources.Res.Energy.ATP *= (1.0 - 0.05 * dt);
+                resources.Res.Carbon.Glucose *= (1.0 - 0.03 * dt);
+                resources.Res.Protein.AminoAcids *= (1.0 - 0.02 * dt);
+            }
+        }
+
+        public cellInfo GetCellInfo()
+        {
+            return new cellInfo
+            {
+                time = this.time,
+                state = this.state,
+                resources = new Dictionary<string, double>
+                {
+                    { "Glucose", resources.Res.Carbon.Glucose },
+                    { "Oxygen", resources.Res.Oxygen },
+                    { "ATP", resources.Res.Energy.ATP },
+                    { "NAD", resources.Res.Energy.NAD },
+                    { "NADH", resources.Res.Energy.NADH },
+                    { "AminoAcids", resources.Res.Protein.AminoAcids }
+                },
+                caState = this.caState
+            };
+        }
+
+    }
+}