InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
@@ -0,0 +1,50 @@
+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Cytosol
+{
+    public class Lactat_Dehydrogenase : InternalEnzym
+    {
+        public Lactat_Dehydrogenase()
+        {
+            Km = 0.5;
+            Vmax = 10;
+
+            KmRange = new(0.05,2);
+            VmaxRange = new(2, 25);
+
+            Km_NADH = 0.05;
+            Km_NADH_Range = new(0.005, 0.2);
+        }
+
+        public double Km_NADH { get; set; }
+
+        public ValueRange Km_NADH_Range { get; set; }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double used = Math.Min(rate * dt, Math.Min(res.Res.Carbon.Pyruvate, res.Res.Energy.NADH));
+
+            //LDH Lactat production and NAD+ regeneration
+            res.Res.Carbon.Pyruvate    -= used;
+            res.Res.Carbon.Lactate     += used;
+            res.TransferNADH(used,true);
+
+            //Consume Protons
+            res.Res.Ions.Protons -= 1.0 * used;
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            double oxscaled = res.Oxygen * 1000;
+            double o2Factor = Math.Max(0.0, 1.0 - oxscaled / (oxscaled + 10.0));
+            rate = Vmax * o2Factor
+              * (res.Carbon.Pyruvate / (Km + res.Carbon.Pyruvate))
+              * (res.Energy.NADH / (Km_NADH + res.Energy.NADH));
+            
+        }
+    }
+}