InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Membrane.GLUT
+{
+    public class GLUT1 : MembranEnzyme
+    {
+        public GLUT1()
+        {
+            Km = 1.5; // Example Km value in mM
+            Vmax = 0.5; 
+
+            KmRange = new(1.0, 3.0);
+            VmaxRange = new(0.1, 10.0);
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double flux = Math.Min(res.Env.Glucose, rate * dt);
+            res.Env.Glucose -= flux;
+            res.Res.Carbon.Glucose += flux;
+        }
+
+        public override double CalculateGradient(CellRessources res)
+        {
+            return res.Env.Glucose - res.Res.Carbon.Glucose;
+        }
+
+        public override void ComputeRate(double gradient, EnviromentState Env)
+        {
+            if (gradient <= 0) 
+            {
+                rate = 0;
+                return;
+            }
+            Michaelis_Menten(gradient);
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Membrane.GLUT
+{
+    public class GLUT2 : GLUT1
+    {
+        public GLUT2()
+        {
+            Km = 17.0; // Example Km value in mM
+            Vmax = 1.2;
+
+            KmRange = new(15.0, 20.0);
+            VmaxRange = new(1.0, 50.0);
+        }
+
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Membrane.GLUT
+{
+    public class GLUT3 : GLUT1
+    {
+        public GLUT3()
+        {
+            Km = 1.0; 
+            Vmax = 0.8; 
+
+            KmRange = new(0.3, 1.0);
+            VmaxRange = new(0.5, 20.0);
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Membrane.GLUT
+{
+    public class GLUT4 : GLUT1
+    {
+        public GLUT4()
+        {
+            Km = 5.0; // Example Km value in mM for GLUT4
+            Vmax = 0.6; // Higher Vmax for GLUT4
+            ActivationThreshold = 0.3; // Example threshold for insulin activation
+
+            KmRange = new(4.0, 6.0);
+            VmaxRange = new(0.2, 15.0);
+        }
+
+        public double ActivationThreshold { get; set; }
+
+        public override void ComputeRate(double gradient, EnviromentState Env)
+        {
+            if (gradient <= 0)
+            {
+                rate = 0;
+                return;
+            }
+            // GLUT4 is insulin-responsive, so we can add an insulin factor
+            double insulinFactor = 0.5 * (Math.Tanh((Env.Insulin - ActivationThreshold) / 0.1) + 1.0); // Example: insulin increases rate up to 3x
+            Michaelis_Menten(gradient);
+            rate *= insulinFactor;
+        }
+    }
+}