InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
@@ -0,0 +1,55 @@
+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Membrane
+{
+    /// <summary>
+    /// Na+/Ca2+ Exchanger (3 Na⁺ in / 1 Ca²⁺ out)
+    /// Einfaches Michaelis-Menten-basiertes Modell mit Gradienten
+    /// </summary>
+    public class NCX : MembranEnzyme
+    {
+        public double NaStoich = 3.0; // Na⁺ pro Ca²⁺
+        public double CaStoich = 1.0;
+
+        /// <summary>
+        /// Berechnet die Transport-Rate abhängig von zellinternen und externen Ionenkonzentrationen
+        /// </summary>
+        public override void ComputeRate(double gradient, EnviromentState env)
+        {
+
+            // Michaelis-Menten-ähnliche Sättigung
+            rate = Vmax * gradient / (Km + Math.Abs(gradient));
+        }
+
+        /// <summary>
+        /// Wendet den Transport auf die Zellressourcen an
+        /// </summary>
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double flux = rate * dt;
+
+            // Na+ in die Zelle
+            res.Res.Ions.Na += NaStoich * flux;
+            res.Env.Na -= NaStoich * flux;
+
+            // Ca2+ aus der Zelle
+            res.Res.Ca.CytosolicCa -= CaStoich * flux;
+            res.Env.Ca += CaStoich * flux;
+
+        }
+
+        public override double CalculateGradient(CellRessources res)
+        {
+            // Gradienten: innen - außen
+            double naGradient = res.Res.Ions.Na - res.Env.Na;       // mM
+            double caGradient = res.Res.Ca.CytosolicCa - res.Env.Ca;       // mM
+
+            // Richtung: positiv = Ca raus / Na rein
+            return (naGradient / NaStoich) - (caGradient / CaStoich);
+        }
+    }
+}