InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+// Noch gemacht werden
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class ANTTransporter : InternalEnzym
+    {
+        public ANTTransporter()
+        {
+            Vmax = 0.3;
+            Km = 0.02; // mM ADP
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double adpAvailable = res.Res.Energy.ADP;
+            double atpAvailable = res.Res.Energy.ATP;
+            double transportable = Math.Min(adpAvailable, rate * dt);
+            transportable = Math.Min(transportable, atpAvailable); // Sicherstellen, dass genug ATP zum Tausch vorhanden ist
+            if (transportable <= 0) return;
+            res.Res.Energy.ADP -= transportable;
+            res.Res.Energy.ATP += transportable;
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            double adp = res.Energy.ADP;
+            Michaelis_Menten(adp);
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class ATPSynthase : InternalEnzym
+    {
+        public ATPSynthase()
+        {
+            Vmax = 0.4;
+            Km = 0.05; // ADP
+        }
+
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+
+            double used = Math.Min(res.Res.Energy.ADP, rate * dt);
+            res.RegenerateATP(used);
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            double gradient = Math.Clamp(res.Energy.NADH / (res.Energy.NAD + 1e-9), 0.0, 5.0);
+            rate = Vmax * (gradient / (Km + gradient));
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class OxPhosEnzyme : InternalEnzym
+    {
+        public double PO_Ratio { get; set; } = 2.5;
+
+        public OxPhosEnzyme()
+        {
+            Vmax = 0.8;
+            Km = 0.01;
+
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double usedNADH = Math.Min(rate * dt, res.Res.Energy.NADH);
+            if (usedNADH <= 0) return;
+
+            res.TransferNADH(usedNADH, true);
+
+            double o2Consumed = 0.5 * usedNADH;
+            res.Res.Oxygen = Math.Max(0.0, res.Res.Oxygen - o2Consumed);
+
+            double atpMade = PO_Ratio * usedNADH;
+            res.RegenerateATP(atpMade);
+
+            // ROS-Produktion
+            double rosFactor = Math.Min(1.0, res.Res.Oxygen / 2.0);
+            res.Res.Ions.H2O2 += usedNADH * 0.001 * rosFactor;
+            res.Res.Protein.Waste += usedNADH * 0.001 * rosFactor;
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            double nadh = res.Energy.NADH;
+            Michaelis_Menten(nadh);
+
+            // Begrenzung durch O2
+            double o2Limit = Math.Min(1.0, res.Oxygen / 0.05);
+            rate *= o2Limit;
+
+            // ATP/ROS Feedback
+            double atpFactor = Math.Clamp(res.Energy.ATP / 0.5, 0.0, 1.0);
+            double wasteFactor = 1.0 / (1.0 + res.Protein.Waste / 10.0);
+            rate *= atpFactor * wasteFactor;
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class PyruvateDehydrogenase : InternalEnzym
+    {
+        public PyruvateDehydrogenase()
+        {
+            Vmax = 1.0; // mM/s
+            Km = 0.05;   // mM Pyruvat
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            Michaelis_Menten(res.Carbon.Pyruvate);
+
+            // Aktivierung durch Ca²⁺
+            double ca = res.Ca.CytosolicCa;
+            double caBoost = 1.0 + 0.8 * (ca / (0.0005 + ca)); // bis ~1.8x Boost
+            rate *= caBoost;
+
+            // Hemmung durch hohes NADH/NAD+ Verhältnis oder ATP
+            double redox = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
+            double energy = res.Energy.ATP / (res.Energy.ATP + res.Energy.ADP + 1e-9);
+            rate *= redox * (1.0 - 0.5 * energy); // Hohe Energie hemmt
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double used = Math.Min(res.Res.Carbon.Pyruvate, rate * dt);
+
+            res.Res.Carbon.Pyruvate -= used;
+            res.Res.Carbon.AcetylCoA += used;
+            res.TransferNADH(used, false);
+            res.Res.Carbon.CO2 += used;
+        }
+    }
+}
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class TCAEnzyme : InternalEnzym
+    {
+        public TCAEnzyme()
+        {
+            Vmax = 0.1; // mM/s
+            Km = 0.02;  // mM Acetyl-CoA
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            Michaelis_Menten(res.Carbon.AcetylCoA);
+            // Abhängig vom Redoxstatus
+            double redox = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
+            rate *= redox;
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double used = Math.Min(res.Res.Carbon.AcetylCoA, rate * dt);
+            res.Res.Carbon.AcetylCoA -= used;
+            res.TransferNADH(2 * used, false);
+            //res.FADH2 += used;
+            res.Res.Energy.GTP += used; // optional
+            res.Res.Carbon.CO2 += 2 * used;
+        }
+    }
+}