InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Mytochondrion
+{
+    public class PyruvateDehydrogenase : InternalEnzym
+    {
+        public PyruvateDehydrogenase()
+        {
+            Vmax = 1.0; // mM/s
+            Km = 0.05;   // mM Pyruvat
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            Michaelis_Menten(res.Carbon.Pyruvate);
+
+            // Aktivierung durch Ca²⁺
+            double ca = res.Ca.CytosolicCa;
+            double caBoost = 1.0 + 0.8 * (ca / (0.0005 + ca)); // bis ~1.8x Boost
+            rate *= caBoost;
+
+            // Hemmung durch hohes NADH/NAD+ Verhältnis oder ATP
+            double redox = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
+            double energy = res.Energy.ATP / (res.Energy.ATP + res.Energy.ADP + 1e-9);
+            rate *= redox * (1.0 - 0.5 * energy); // Hohe Energie hemmt
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            double used = Math.Min(res.Res.Carbon.Pyruvate, rate * dt);
+
+            res.Res.Carbon.Pyruvate -= used;
+            res.Res.Carbon.AcetylCoA += used;
+            res.TransferNADH(used, false);
+            res.Res.Carbon.CO2 += used;
+        }
+    }
+}