InitalCommit

2025-11-16 10:30:26 +01:00
parent 8b0b73bba8
commit d2e409d10f
73 changed files with 3209 additions and 0 deletions
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+using System;
+using System.Collections.Generic;
+using System.Linq;
+using System.Text;
+using System.Threading.Tasks;
+
+namespace BaseCellSimulation.Enzyms.Nucleus
+{
+    public class DNMT1 : InternalEnzym
+    {
+        public DNMT1()
+        {
+            Km = 0.01;
+            Vmax = 0.25;
+        }
+
+        public override void ApplyChanges(CellRessources res, double dt)
+        {
+            // Berechne tatsächlich übertragene Methylmenge
+            double dMethyl = Math.Min(rate * dt, res.Res.Protein.SAM);
+
+            // Chromatinzugänglichkeit moduliert Effektivität
+            double accessibilityFactor = Math.Clamp(res.Res.Nucleus.ChromatinAccessibility / 0.005, 0.1, 1.0);
+            dMethyl *= accessibilityFactor;
+
+            // SAM → SAH Umwandlung
+            res.Res.Protein.SAM -= dMethyl;
+            res.Res.Protein.SAH += dMethyl;  // 1:1 Bildung
+
+            // Methylierung der DNA (vereinfachte Darstellung)
+            res.Res.Nucleus.ChromatinAccessibility -= dMethyl * 0.005;
+            if (res.Res.Nucleus.ChromatinAccessibility < 0)
+                res.Res.Nucleus.ChromatinAccessibility = 0;
+        }
+
+        public override void ComputeRate(Resources res)
+        {
+            double activityFactor = Math.Min(1.0, res.Nucleus.ReplicationProgress / 10.0);
+            Michaelis_Menten(res.Protein.SAM * activityFactor);
+            rate *= activityFactor;
+        }
+    }
+}