using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Threading.Tasks;

namespace BaseCellSimulation.Enzyms.Lysosome
{
    public class GenericLysosomalEnzyme : InternalEnzym
    {
        public GenericLysosomalEnzyme()
        {
            Vmax = 0.2;
            Km = 0.1;
        }

        double redoxRatio = 0.0;

        public override void ComputeRate(Resources res)
        {
            // --- Grundrate basierend auf Protein-Waste ---
            rate = Michaelis_Menten(res.Protein.Waste, Vmax, Km);

            // --- Energieabhängigkeit ---
            double energyCharge = (res.Energy.ATP + 0.5 * res.Energy.ADP) /
                                  (res.Energy.ATP + res.Energy.ADP + res.Energy.AMP + 1e-9);
            rate *= Math.Clamp(energyCharge, 0.0, 1.0);

            // --- Redoxabhängigkeit ---
            redoxRatio = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
            rate *= Math.Clamp(redoxRatio, 0.0, 1.0);

            // --- pH-Abhängigkeit ---
            double acidFactor = 1.0 - 0.5 * Math.Clamp(res.Ions.Protons / 1.0, 0.0, 1.0);
            rate *= acidFactor;

            // --- Stressfaktor bei hohen ROS ---
            double stressPenalty = res.Ions.ROS > 1.0 ? 0.5 : 1.0;
            rate *= stressPenalty;
        }

        public override void ApplyChanges(CellRessources Resources, double dt)
        {
            var res = Resources.Res;
            var ca = Resources.Res.Ca;

            ComputeRate(res);

            double degraded = Math.Min(res.Protein.Waste, rate * dt);
            if (degraded <= 0.0)
                return;

            // --- Protein-Abbau ---
            res.Protein.Waste -= degraded;

            // --- Energieverbrauch & minimale Rückgewinnung ---
            double atpUsed = degraded * 0.15;
            double atpRecovered = degraded * 0.03 * ((res.Energy.ATP + 0.5 * res.Energy.ADP) /
                                                    (res.Energy.ATP + res.Energy.ADP + res.Energy.AMP + 1e-9));
            Resources.ConsumeATP(atpUsed);
            res.Energy.ATP += atpRecovered;

            // --- NAD+ → NADH Redoxreaktion ---
            double nadUsed = degraded * 0.08;
            double actualNadUsed = Math.Min(nadUsed, res.Energy.NAD);
            res.Energy.NAD -= actualNadUsed;
            res.Energy.NADH += actualNadUsed;

            // --- Aminosäuren-Recycling ---
            double recyclingEfficiency = 0.4 + 0.3 * ((res.Energy.ATP + 0.5 * res.Energy.ADP) /
                                                     (res.Energy.ATP + res.Energy.ADP + res.Energy.AMP + 1e-9));
            res.Protein.AminoAcids += degraded * recyclingEfficiency;

            // --- Sekundäre Effekte: ROS, Heat, Protonen ---
            res.Ions.ROS += degraded * (1.0 - redoxRatio) * 0.01;
            res.Heat += degraded * 0.05;
            res.Ions.Protons += degraded * 0.005;

            // --- Kalziumleckage als Stresssignal ---
            ca.CytosolicCa += degraded * 0.00002;

            // --- Lysosomenaktivität für Feedback ---
            ca.LysosomeActivity = Math.Clamp(rate / Vmax, 0.0, 1.0);
        }
    }


}