using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Threading.Tasks;

namespace BaseCellSimulation.Enzyms.Mytochondrion
{
    public class PyruvateDehydrogenase : InternalEnzym
    {
        public PyruvateDehydrogenase()
        {
            Vmax = 1.0; // mM/s
            Km = 0.05;   // mM Pyruvat
        }

        public override void ComputeRate(Resources res)
        {
            Michaelis_Menten(res.Carbon.Pyruvate);

            // Aktivierung durch Ca²⁺
            double ca = res.Ca.CytosolicCa;
            double caBoost = 1.0 + 0.8 * (ca / (0.0005 + ca)); // bis ~1.8x Boost
            rate *= caBoost;

            // Hemmung durch hohes NADH/NAD+ Verhältnis oder ATP
            double redox = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
            double energy = res.Energy.ATP / (res.Energy.ATP + res.Energy.ADP + 1e-9);
            rate *= redox * (1.0 - 0.5 * energy); // Hohe Energie hemmt
        }

        public override void ApplyChanges(CellRessources res, double dt)
        {
            double used = Math.Min(res.Res.Carbon.Pyruvate, rate * dt);

            res.Res.Carbon.Pyruvate -= used;
            res.Res.Carbon.AcetylCoA += used;
            res.TransferNADH(used, false);
            res.Res.Carbon.CO2 += used;
        }
    }
}