43 lines
1.3 KiB
C#
43 lines
1.3 KiB
C#
using System;
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using System.Collections.Generic;
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using System.Linq;
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using System.Text;
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using System.Threading.Tasks;
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namespace BaseCellSimulation.Enzyms.Mytochondrion
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{
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public class PyruvateDehydrogenase : InternalEnzym
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{
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public PyruvateDehydrogenase()
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{
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Vmax = 1.0; // mM/s
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Km = 0.05; // mM Pyruvat
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}
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public override void ComputeRate(Resources res)
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{
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Michaelis_Menten(res.Carbon.Pyruvate);
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// Aktivierung durch Ca²⁺
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double ca = res.Ca.CytosolicCa;
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double caBoost = 1.0 + 0.8 * (ca / (0.0005 + ca)); // bis ~1.8x Boost
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rate *= caBoost;
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// Hemmung durch hohes NADH/NAD+ Verhältnis oder ATP
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double redox = res.Energy.NAD / (res.Energy.NAD + res.Energy.NADH + 1e-9);
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double energy = res.Energy.ATP / (res.Energy.ATP + res.Energy.ADP + 1e-9);
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rate *= redox * (1.0 - 0.5 * energy); // Hohe Energie hemmt
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}
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public override void ApplyChanges(CellRessources res, double dt)
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{
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double used = Math.Min(res.Res.Carbon.Pyruvate, rate * dt);
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res.Res.Carbon.Pyruvate -= used;
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res.Res.Carbon.AcetylCoA += used;
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res.TransferNADH(used, false);
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res.Res.Carbon.CO2 += used;
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}
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}
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}
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